Modification oligonucleotides:

Classification

Modification/ labelling

Purification

1OD

2OD

5OD

50 nmol

100nmol

200 nmol

Rare bases

dI

HPLC

$5

$6

$7

dU

HPLC

$5

$6

$7

Spacer 9

Spacer 9

HPLC

$32

$40

$48

Spacer 18

Spacer 18

HPLC

$42

$45

$55

Phosphorothioate

S

HPLC

$2.00/base

$2.5/base

$2.8/base

Phosphorylation

5′ PHO

HPLC

$12

$15

$18

3′ PHO

HPLC

$13

$17

$20

Amino Linkers

5′ NH2 C6

HPLC

$14

$18

$21

3′ NH2 C7

HPLC

$14

$18

$21

5′ NH2 C12

HPLC

$40

$42

$55

Internal NH2 C6 dT

HPLC

$80

$90

$115

Thiol

3′ SH C3

HPLC

$45

$53

$63

5′ SH C6

HPLC

$50

$60

$73

Biotin

5′ Biotin

HPLC

$42

$50

$60

3′ Biotin TEG

HPLC

$45

$55

$65

Internal Biotin dT

HPLC

$115

$125

$140

Digoxigen

5′ DIG

HPLC

$50

$60

$80

3′ DIG

HPLC

$55

$65

$85

Fluorescence

5′ Cy3

HPLC

$65

$75

$95

3′ Cy3

HPLC

$80

$92

$115

Internal Cy3 dT

HPLC

$138

$152

$185

5′ Cy5

HPLC

$65

$75

$95

3′ Cy5

HPLC

$80

$92

$115

Internal Cy5 dT

HPLC

$138

$152

$185

5′ FAM

HPLC

$42

$50

$65

3′ FAM

HPLC

$42

$50

$65

5′ Cy5.5

HPLC

$65

$75

$95

3′ Cy5.5

HPLC

$80

$92

$115

5′ Cy7.5

HPLC

$65

$75

$95

5′ Cy7.5

HPLC

$80

$92

$115

5′Texas Red-X

HPLC

$65

$75

$95

5′ HEX

HPLC

$42

$50

$65

5′ TET

HPLC

$50

$60

$75

5′ 6-JOE

HPLC

$125

$145

$155

3′ 6-JOE

HPLC

$128

$148

$160

5′ ROX

HPLC

$80

$90

$105

3′ ROX

HPLC

$85

$95

$110

5′ TAMRA

HPLC

$76

$85

$100

3′ TAMRA

HPLC

$78

$88

$105

Internal TAMRA dT

HPLC

$125

$145

$175

Quenchers

3′ DABCYL

HPLC

$58

$65

$75

3′ BHQ 1

HPLC

$58

$65

$75

3′ BHQ 2

HPLC

$58

$65

$75

Dual-labeled fluorescent probes

TAMRA

5′ FAM-3′ TAMRA

HPLC

$115

$130

$150

5′ HEX-3′ TAMRA

HPLC

$115

$130

$160

5′ TET-3′ TAMRA

HPLC

$115

$135

$165

5′ JOE-3′ TAMRA

HPLC

$165

$175

$190

DABCYL

5′ FAM-3′ DABCYL

HPLC

$100

$110

$130

5′ HEX-3′ DABCYL

HPLC

$100

$110

$130

5′ TET-3′ DABCYL

HPLC

$100

$110

$130

5′ JOE-3′ DABCYL

HPLC

$155

$170

$200

5′ TAMRA-3′ DABCYL

HPLC

$135

$160

$190

5′ Cy5-3′ DABCYL

HPLC

$100

$110

$130

BHQ1

5′ FAM-3′ BHQ1

HPLC

$95

$105

$125

5′ HEX-3′ BHQ1

HPLC

$95

$105

$125

5′ JOE-3′ BHQ1

HPLC

$150

$165

$195

BHQ2

5′ ROX-3′ BHQ2

HPLC

$105

$115

$135

5′ Cy5-3′ BHQ2

HPLC

$105

$115

$135

5′ Cy3-3′ BHQ2

HPLC

$105

$115

$135

BHQ3

5′ Cy5-3′ BHQ3

HPLC

$135

$145

$165

Eclipse

5′ FAM-3′ Eclipse

HPLC

$125

$135

$155

5′ HEX-3′ Eclipse

HPLC

$135

$150

$170

5′ JOE-3′ Eclipse

HPLC

 $150

$165

$195

MGB

5′ FAM-3′ MGB

HPLC

$450

$470

$500

5′ HEX-3′ MGB

HPLC

$470

$490

$520

5′ VIC-3′ MGB

HPLC

$500

$520

$550